Contraindicated (1)pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with powerful CYP3A4 inducers; these medication lower exposure to vandetanib by up to 40%.pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 me

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